Regulation of type 2 nitric oxide synthase by type 1 interferons in macrophages infected withLeishmania major

Kinetics of Nitric Oxide Production and MTT Reduction by HSV-1 Infected Macrophages

Background: Macrophages have important role in defense against Herpes Simplex Virus type-1 (HSV-1). The present study was performed to determine the viability and nitric oxide (NO) production by HSV-1 infected mouse peritoneal macrophages (HIM). Method: The viability of macrophages was evaluated using MTT reduction assay and the production of nitrite using Griess method. Results: The ability of...

Is Shaped by the Pattern of l-Arginine Cytokines In Vivo: Granulomatous Pathology Synthase-2 and Arginase-1 by Type 1/Type 2 Differential Regulation of Nitric Oxide

Association of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy

Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...

kinetics of nitric oxide production and mtt reduction by hsv-1 infected macrophages

background: macrophages have important role in defense against herpes simplex virus type-1 (hsv-1). the present study was performed to determine the viability and nitric oxide (no) production by hsv-1 infected mouse peritoneal macrophages (him).   method: the viability of macrophages was evaluated using mtt reduction assay and the production of nitrite using griess method.   results: the abilit...

Inhibition of Nitric Oxide Synthase 1 Induces Salt-Sensitive Hypertension in Nitric Oxide Synthase 1α Knockout and Wild-Type Mice.

We recently showed that α, β, and γ splice variants of neuronal nitric oxide synthase (NOS1) expressed in the macula densa and NOS1β accounts for most of the NO generation. We have also demonstrated that the mice with deletion of NOS1 specifically from the macula densa developed salt-sensitive hypertension. However, the global NOS1 knockout (NOS1KO) strain is neither hypertensive nor salt sensi...